Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 23;25(11):2832–2843. doi: 10.1038/s41380-018-0124-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a Increased number of cFos-positive nuclei in hippocampal CA3. Left panel, representative images in cont and DG-GluN1 KO brains. Middle panel, the total number of cFos-positive nuclei was significantly increased in CA3 (t(8) = 2.665, *p = 0.02). Right panel, the number of cFos-positive nuclei over the rostral (dorsal)-caudal (ventral) axis of CA3 of the hippocampus (−1.46 to −2.92 mm from Bregma). Two-way ANOVA analyses show significant genotype, hippocampal rostral-caudal axis, and genotype × hippocampal rostral-caudal axis interaction in CA3 (genotype effect: F(6, 56) = 4.635, ***p = 0.0007; hippocampal rostral-caudal axis effect: F(1, 56) = 24.53, ****p < 0.0001; and interaction effect: F(6, 56) = 2.634, *p = 0.0254). Post hoc comparison further demonstrates significant increased cFos-positive nuclei in the caudal (ventral) CA3 (*p = 0.01 at −2.70 mm from Bregma, ****p < 0.0001 at −2.92 mm from Bregma). b Increased cFos-positive nuclei in hippocampal CA1. Left panel, representative images. Middle panel, increased total number of cFos-positive nuclei in CA1 (t(8) = 2.614, *p = 0.03). Right panel, the number of cFos-positive nuclei over the rostral-caudal axis of CA1 of the hippocampus (−1.46 to −2.92 mm from Bregma). Two-way ANOVA analyses show significant genotype, hippocampal rostral-caudal axis, and genotype × hippocampal rostral-caudal axis interaction in CA1 (genotype effect: F(6, 56) = 8.286, ****p < 0.0001; hippocampal rostral-caudal axis effect: F(1, 56) = 18.34, ****p < 0.0001; and interaction effect: F(6, 56) = 3.374, **p = 0.0066). Post hoc comparison further demonstrates significant increased cFos-positive nuclei in the caudal CA1 (***p = 0.0007 at −2.70 mm from Bregma, ***p = 0.0005 at −2.92 mm from Bregma). c Increased number of cFos-positive nuclei in basolateral amygdala (BLA, −0.70 to −2.30 mm from Bregma, t(8) = 2.709, *p = 0.02). Left panel, representative images. d The majority of cFos-positive nuclei in hippocampal pyramidal layer in CA3 subfield were located within CaMKII-positive excitatory neurons, but not within GAD-67-positive inhibitory neurons