Table 3.
Cox proportional hazard ratios according to MIC and classifications based on two biomarkers
| Classification | Range | Unit | Subjects (n) | Cox proportional hazard analysis | ||
|---|---|---|---|---|---|---|
| Multivariate HR | 95% CI | FDR-adjusted P value | ||||
| MIC by AHTKV-α* | ||||||
| 1A + 1B | < 3.0 | %/year | 80 | 1 | ||
| 1C | 3.0–4.5 | 112 | 1.31 | 0.03–2.58 | 0.0443 | |
| 1D + 1E | 4.5 ≤ | 104 | 3.36 | 2.00–4.71 | < 0.0001 | |
| Three equally divided subgroups for baseline AHTKV-α | ||||||
| A | < 3.175 | %/year | 100 | 1 | ||
| B | 3.175–4.53 | 98 | 1.62 | 0.46–2.79 | 0.006 | |
| C | 4.53 ≤ | 98 | 3.49 | 2.26–4.73 | < 0.0001 | |
| Three equally divided subgroups for baseline-measured HtTKV slope | ||||||
| A | < 1.748 | %/year | 98 | 1 | ||
| B | 1.748–7.91 | 99 | 0.11 | − 0.71–0.92 | 0.799 | |
| C | 7.91 ≤ | 99 | − 0.62 | − 1.66–0.41 | 0.361 | |
Multivariate hazard ratios (HR) were for worse adjacent subgroups. P values were compared between adjacent subgroups
MIC Mayo Image Classification for ADPKD, AHTKV-α age- and height-adjusted TKV growth rate as described in the text, TKV total kidney volume, HtTKV height-adjusted TKV, FDR false discovery rate