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. 2019 Jan 17;9:3353. doi: 10.3389/fmicb.2018.03353

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Copyright © 2019 Inoue, Nakamoto, Omae, Oguro, Ogata, Yoshida and Sako.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phylogenetic relationships of Ni-CODHs. An unrooted phylogenetic tree was constructed using an alignment of 1942 Ni-CODHs. Major clades A through G are highlighted by different colors as follows: red, clade A; yellow, clade B; cyan, clade C; gray, clade D; green, clade E; purple, clade F; and magenta, clade G. The number of proteins in each clade is designated. Subclades are assigned by the structural groups and colored in blue (related to Figure 2). The number of proteins in each structural group is shown in parentheses, and the total number of proteins in each subclade is designated. The branches separating the major clades or subclades are encircled and colored according to their bootstrap values, with black and red circles indicating >0.90 and <0.90 support, respectively.