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. 2019 Jan 17;11:495. doi: 10.3389/fnmol.2018.00495

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Copyright © 2019 Yau, Bettio, Chiu, Chiu and Christie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreased NMDAR-mediated EPSC in dentate granule cells of Fmr1 KO mice. (A) Representative traces of granule neurons. Neurons with a single primary dendrite (left panel) and neurons with multiple dendrites (right panel) at maximal amplitude were shown. (B) No significant difference in AMPAR-mediated EPSC was observed between Fmr1 KO and WT mice. (C) A trend toward a lower NMDAR-mediated EPSC was found in Fmr1 KO mice when compared to WT mice (P = 0.067). (D) No significant difference in AMPAR-mediated EPSCs of older granule neurons was observed between Fmr1 KO and WT mice; (E) but a significant decrease in NMDAR-mediated EPSC was observed in Fmr1 KO mice when compared to WT mice. ^∗P < 0.005 (n = 9–14; five mice per group; ANOVA, repeated measures).