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. 2019 Jan 17;11:491. doi: 10.3389/fnmol.2018.00491

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Copyright © 2019 Wever, von Oerthel, Wagemans and Smidt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ahd2 expression is reduced in En1Cre/+; Ezh2 L/L embryos at E14.5. (A) In situ hybridization for Th, Cck, and Ahd2 in sagittal E14.5 midbrain sections. Ahd2 expression is reduced in both lateral en medial sections (lowest panel, arrowheads), while Th expression is decreased only in the lateral sections (upper panel, arrowhead). Expression of Cck was found ectopically in the rostral midbrain (arrows). (B) Quantification of the expression levels of Th, Cck, and Ahd2 via qPCR showed that Th and Cck levels were not significantly altered in the En1Cre/+; Ezh2 L/L (gray bars), but levels of Ahd2 were reduced to ∼20% of the wildtype level (black bar) (n = 3, ^∗P < 0.05, two-tailed). Wildtype levels were set at 1. Scale bars = 280 μM.