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. 2019 Jan 17;9:778. doi: 10.3389/fpsyt.2018.00778

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Copyright © 2019 Lori, Maddox, Sharma, Andero, Ressler and Smith.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fear conditioning induces gene expression differences in amygdala and blood. Volcano plots and heatmaps show changes in gene expression in the amygdala (A) and blood (B) after fear conditioning compared to Home Cage (HC vs. FC). The horizontal axis of the Volcano plot is log₂ fold change for differently expressed genes, and the vertical axis is the negative-log₁₀ of the p-values are plotted. Each dot represents a gene, with red dots showing genes reaching an FDR corrected p-value of 0.05, and green dots representing genes with FDR < 0.05 and absolute fold change >1; orange dots have an absolute fold change>1 but do not reach experiment-wide significance; black dots are genes whose expression is similar between the two groups.