Table 2.
Multivariate Cox proportional hazard ratio analysis to identify predictive factors for overall survival.
| Parameter | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% Cl) | P-value | HR (95% Cl) | P-value | |
| Age | 1.11 (1.07–1.15) | 0.000 | 1.08 (1.05–1.10) | 0.000 |
| NLR | ||||
| NLR < 1.5 | Reference | Reference | ||
| NLR ≥ 1.5 | 1.94 (0.82–4.58) | 0.012 | 2.24 (1.26–3.96) | 0.005 |
| dNLR | ||||
| dNLR < 1.2 | Reference | Reference | ||
| dNLR ≥ 1.2 | 2.12 (1.16–4.11) | 0.010 | 1.65 (0.98–2.55) | 0.050 |
| PLR | ||||
| PLR < 171 | Reference | Reference | ||
| PLR > 171 | 0.92 (0.46–1.82) | 0.819 | 0.74 (0.39–1.39) | 0.357 |
| Hb | 0.82 (0.72–0.94) | 0.005 | 0.80 (0.68–0.95) | 0.011 |
| T STAGE | ||||
| <T1 | Reference | Reference | ||
| T1 | 1.98 (1.19–3.30) | 0.008 | 1.99 (1.09–3.64) | 0.025 |
| TUMOR GRADE | ||||
| Low | Reference | Reference | ||
| High | 2.15 (0.88–5.24) | 0.089 | 1.76 (0.73–4.25) | 0.209 |
| Concomitant CIS | 1.65 (0.93–2.93) | 0.089 | 1.95 (0.98–3.86) | 0.054 |
| LVI | 4.71 (1.15–19.32) | 0.031 | 1.67 (0.59–4.73) | 0.335 |
| Tumor Number | 0.264 | 0.780 | ||
| 1 | Reference | Reference | ||
| 2~7 | 1.57 (0.89–2.78) | 0.123 | 1.21 (0.70–2.04) | 0.482 |
| ≥3 | 1.07 (0.44–2.57) | 0.888 | 1.11 (0.48–2.52) | 0.809 |
| TUMOR SIZE | ||||
| <3 cm | Reference | Reference | ||
| ≥3 cm | 1.30 (0.76–2.24) | 0.332 | 1.61 (0.83–3.13) | 0.162 |
NLR, neutrophil-to-lymphocyte ratio; dNLR, derived NLR; PLR, platelet-lymphocyte ratio; Hb, hemoglobin; CIS, carcinoma in situ; LVI, lymphovascular invasion.