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. 2019 Jan 17;8:652. doi: 10.3389/fonc.2018.00652

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Copyright 2019 Ghatalia, Smith, Winer, Gou, Kiedrowski, Slifker, Saltzberg, Bubes, Anari, Kasireddy, Varshavsky, Liu, Ross and El-Deiry.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between CEA as a marker of tumor burden and number of alterations or maximal allele frequency found in liquid biopsy from patients with metastatic colorectal cancer. Scatter plot colored by smoothed density demonstrating correlation between maxpct and number of alts with CEA. Plots include data from all available blood samples. There is a direct correlation between maxpct with CEA (Kendall's Tau = 0.436; p = 0.001) and number of alts with CEA (Kendall's Tau = 0.451; p < 0.001). The values circled in red represent three patients who never had elevated CEA despite high burden of metastatic disease. One of these patients had four serial liquid biopsies.