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. 2019 Jan 23;9:376. doi: 10.1038/s41598-018-36700-w

Figure 2.

Figure 2

Non-infectious recombinant PrP fibrils and infectious RML PrP rods imaged with high resolution AFM tips. (a–c) Representative 2D surface topography images. (a) Recombinant fibrils have an average width of 10.4 ± 1.2 nm and an average height of 4.0 ± 0.8 nm. The graph plots height profiles at the positions of the solid and dotted lines. (b) RML prion rods have a fibre height of 9.2 ± 0.5 nm and an overall width of 26.5 ± 0.3 nm. The height of the central gap material is 7.4 ± 0.8 nm. (c) RML prion rods have repeating structure at 6.3 ± 0.4 nm intervals along the length of the fibres (solid line) and have material with a more irregular structure down the 8–10 nm central gap of the rod (dotted line) that separates the paired fibres. The tip broadening artefacts displayed in the raw profiles are removed through deconvolution for the calculation of dimensions given above and in Table 1. Scale bars, 10 nm.