Fig. 2.

The catalytic AsfvLIG:DNA complex structures. a The overall structure of AsfvLIG:CT1 complex demonstrating the arrangement of individual domains in the catalytic form complex. AsfvLIG and DNA are shown as surface and cartoon, respectively. b Comparison of the catalytic form complexes of AsfvLIG and HsLIG1 (PDB_ID: 1 × 9 N). DNAs are colored in white, whereas the ligase NTD (or DBD), AD and OB domains are colored in magenta, yellow and green, respectively. In the HsLIG1 structure, the AMP that pyrophosphate linked to the 5′-P downstream of the DNA is shown as red spheres