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. 2019 Jan 23;9:389. doi: 10.1038/s41598-018-37117-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of BDNF on thrombin generation. Recombinant BDNF (rh-BDNF; 120 pg/ml) or BSA (1 mg/ml: control) was added to platelet-free plasma and thrombin formation was measured by CAT assay. Thrombin generated (a) by the concomitant activation of both intrinsic and extrinsic coagulation pathways and (b) only by the extrinsic pathway. (i) Representative curves of the kinetic of thrombin formation. (ii) Endogenous thrombin potential (ETP, area under the curve), (iii) Peak Height (maximum concentration of generated thrombin) and (iv) Velocity Index (velocity of thrombin formation) were used as main parameters describing thrombin generation. Data are expressed as mean ± SEM; horizontal bars indicate variation of BDNF levels measured in plasma pools analyzed n = 5 different pools. *p < 0.05 and **p < 0.01.