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. 2019 Jan 23;9:343. doi: 10.1038/s41598-018-36122-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Efficacy of overexpression across all genes. Heat map demonstrating the efficacy of gene overexpression across all experiments (A). Columns are overexpressed genes and the rows are experiments. Green color refers to lower, while red means higher expression in the treated sample compared to control. Genes and experiments are ranked so that the diagonal (red) line corresponds to the overexpression efficacy of the targeted gene in the particular experiment. A ranked order of all genes based on fold change (B). Values below one indicate down-regulation, values over one indicate up-regulation. The dotted red line shows 1.44x fold change. Robust gene induction was confirmed in 39% of all genes.