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. 2019 Jan 23;4:4. doi: 10.1038/s41541-019-0098-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Vaccination with OVX836 induces broad protection against lethal challenge with different influenza A subtypes. Groups of 12 female Balb/c mice received two 21 days apart intramuscular (i.m.) immunizations with either PBS, inactivated influenza vaccine (IIV), OVX836, or a combination of IIV and OVX836 (OVX836/IIV). Three weeks after the second immunization, mice were intranasally (i.n.) infected with either 3LD50 of influenza H1N1 A/California/7/2009 (left panel) or 1LD50 of H3N2 A/Victoria/5/72 (right panel) virus. a, b Percent survival rates. *p < 0.05, **p < 0.01 and ***p < 0.001 by log-rank (Mantel–Cox), c, d mean weight changes (±SEM), e, f mean lung viral titers expressed as log (PFU/mL ± SD) on day 4 or 5 post-infection. Individual virus titers are given and lines represent averages. In all, 1.7 log PFU/mL is the detection limit of the technique (dotted line). Statistical significance of the variance between multiple groups was calculated with Kruskal–Wallis test followed by Dunn’s multiple comparison test (*p < 0.05, ***p < 0.001,****p < 0.0001)