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. 2019 Jan 23;9:359. doi: 10.1038/s41598-018-36897-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Area under the Curve (AUC) analysis for C57BL/6 N mice. (A) AUC scores for C57BL/6 N mice that were treated with carprofen (10 and 25 mg/kg), meloxicam (2 and 5 mg/kg) and buprenorphine (0.1 mg/kg). For each condition, the scores of individual mice are presented as a dot plot with injectable analgesics indicated by the green circles and analgesics administered through the water supply as orange circles. In contrast with CD-1 mice, MGS scores for the carprofen (25 mg/kg) and meloxicam (5 mg/kg) groups were significantly lower than control mice. (B) Overall higher MGS scores were found in CD-1 control mice when compared with C57BL/6 N mice. *p < 0.05; **p < 0.01, ***p < 0.001.