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. 2019 Jan 23;5:5. doi: 10.1038/s41522-018-0073-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Taxonomic drivers of functional shifts associated with KD. Taxonomic contributions to the shift in each function are shown as bars for functions enriched pre-KD compared to post-KD a and functions enriched post-KD compared to pre-KD b. Bar length represents the size of the contribution. For each function, the position of the bar indicates the type of contribution. The top (bottom) bars represent contributions from genera with higher (lower) relative abundance in the enrichment group (pre-KD for a, post-KD for b). Bars to the left (right) of the vertical black line represent contributions to decreased (increased) function abundance in the enrichment group. The red diamonds indicate the observed increase in relative median function abundance in pre-KD samples a or post-KD samples b. Colors indicate the genus, with genera from the same phylum sharing similar colors: green for Actinobacteria; orange for Bacteroidetes; teal, blue, and purple for Firmicutes; and red for Proteobacteria. Genus labels within bars are provided for genera with notable contributions where bars were wide enough to accommodate labels