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. 2019 Jan 23;9:321. doi: 10.1038/s41598-018-36340-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sample T1 weighted post-gadolinium MRI from patient five obtained 30 days prior to BBB opening procedure (left), immediately following BBB disruption (middle) and 20 hours post BBB disruption (right). Ill-defined contrast enhancement is seen in the peritumoral region on images acquired immediately after MRgFUS (white arrows). This contrast enhancement has resolved in the peritumor region on the day 1 follow-up image indicating closure of the BBB. T2* sequence acquired immediately following BBB disruption for this patient show no evidence of microhemorrhages.