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. 2019 Jan 23;9:368. doi: 10.1038/s41598-018-36863-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IGF1 increases the size and cusp number of bioengineered teeth developed in subrenal capsules. Stereomicroscopy images (a) and micro-CT images (b) of bioengineered teeth at 30 days after renal subcapsular transplantation in the control and IGF1-treated groups. Scale bar, 600 µm. The height (c), width (d), and cusp number (e) of bioengineered teeth at 30 days after renal subcapsular transplantation in the control and IGF1-treated groups. Error bars indicate the standard deviation (N = 7 or 8). *p < 0.05 (versus control group; Student’s t-test).