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. 2019 Jan 23;9:363. doi: 10.1038/s41598-018-36629-0

Table 2.

Interaction Term P-values between Polygenic Scores and Environmental Factors in Predicting Adiposity in the Total Sample, and by Sex Group.

N BMI predicted by BMI PGS WHR predicted by WHRadjBMI PGS
Total 111 819 Men 53 065 Women 58 754 Total 111 956 Men 53 147 Women 58 809
Smoking
  current vs never 0.354 0.685 0.911 0.170 0.238 0.994
  previous vs never 0.481 0.068 0.040 0.147 0.668 0.881
Alcohol
  gpda 0.132 0.376 0.440 0.035 0.722 0.331
  none vs 8–16 g 5.34 × 10 −12 0.060 8.44 × 10 −10 0.069 0.893 0.265
  <8 g vs 8–16 g 1.71 × 10 −4 0.156 0.004 0.099 0.835 0.848
  >24 g vs 8–16 g 0.611 0.992 0.746 0.174 0.581 0.906
  16–24 g vs 8–16 g 0.071 0.695 0.844 0.065 0.857 0.401
Physical activity
  MET mins/weekb 2.19 × 10–14 0.002 2.06 × 10 −9 0.067 0.082 0.137
  moderate vs low 1.03 × 10 −11 0.003 4.03 × 10 −6 0.320 0.786 0.834
  high vs low 6.35 × 10 −18 7.31 × 10 −5 4.19 × 10 −10 0.029 0.091 0.422
Education
  graduate vs non 6.33 × 10 −5 0.474 3.89 × 10 −4 0.353 0.890 0.085
Income
  mean income 1.19 × 10 −10 0.002 0.010 0.007 0.582 7.40 × 10 −4
  £18–£31 k vs <£18 k 0.004 0.023 0.785 0.006 0.069 0.197
  £31–£52 k vs <£18 k 2.21 × 10 − 4 0.115 0.209 0.002 0.769 0.020
  £52–£100 k vs <£18 k 4.61 × 10 −8 0.002 0.116 0.004 0.356 0.002
  >£100 k vs <£18 k 6.76 × 10 −7 0.006 0.017 0.132 0.293 0.093
Deprivation
  Townsend score 7.62 × 10 −14 7.06 × 10 −7 5.60 × 10 −8 0.031 0.066 0.033
  2nd quartile vs 1st 0.398 0.241 0.747 0.109 0.912 0.188
  3rd quartile vs 1st 0.002 0.015 0.543 0.030 0.844 0.004
  4th quartile vs 1st 2.36 × 10 −9 2.43 × 10 −6 9.19 × 10 −6 0.013 0.286 0.007
Cognitive ability
  score 0.787 0.196 0.641 0.285 0.824 0.596
Neuroticism
  score 0.058 0.543 0.085 0.003 0.345 0.119
  2nd quartile vs 1st 0.700 0.162 0.813 0.784 0.138 0.664
  3rd quartile vs 1st 0.809 0.469 0.873 0.863 0.809 0.696
  4th quartile vs 1st 0.209 0.139 0.055 0.003 0.270 0.138

Statistically significant p-values in bold survive correction for multiple testing according to FDR (p ≤ 0.017 for 78 BMI models; p ≤ 0.004 for 78 WHR models). For the total sample, significant 3-way interaction terms for Sex*BMI PGS*[Exposure] were observed for Alcohol (none vs 8–16 g): p = 0.008, and Physical activity (MET mins/week): p = 0.009 (see Tables S7 and S8 for coefficients of these models). aModel includes drinkers of 1 unit (8 g) or more per day. bSquare-root value used for normality.