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. 2019 Jan 23;9:339. doi: 10.1038/s41598-018-36292-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Untargeted plasma metabolome by GC-MS reveals a difference between breast-fed (BF, green) and formula-fed (Experimental Formula, EF, orange; Standard Formula, SF, red) infants at 6 months of age. (a) Principal component analysis (PCA) of generalized log transformed intensity data. The corresponding plasma metabolites significantly different between (b) BF and formula-fed, and between (c) SF and EF infants at 6 months of age. The 95% confidence interval was estimated using the normal distribution. The number of samples from each group is summarized in SI Table 3.