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. 2019 Jan 23;9:421. doi: 10.1038/s41598-018-36844-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Similar abnormal B-cell development in both Itch cKO and Foxo1 cKO mice. Representative FACS profiles (a) and the absolute numbers (b) of CD3⁺B220⁻ and CD3⁻B220⁺ B cells and representative flow cytometry profiles (c) and the absolute numbers (d) of IgM⁺IgD⁺B cells and IgM⁻IgD⁻B-cells in gated CD3⁻B220⁺ B cells in BM, spleen, LNs, and PBMCs from CD19^creItch^F/+Foxo1^F/+ (WT), CD19^creItch^F/FFoxo1^F/+ (Itch cKO), CD19^creItch^F/+Foxo1^F/F (Foxo1 cKO), and CD19^creItch^F/FFoxo1^F/F mice (Itch-Foxo1 cDKO) (n = 20 mice per group, 7~9 weeks old). One-way (b) and two-way (d) ANOVA plus Bonferroni post-tests to compare each column with control column. Error bars, s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001.