Fig. 1.

α-Gal syndrome. The α-Gal syndrome describes an IgE-mediated allergy to the disaccharide galactose-α-1,3-galactose (α-Gal). Base arc—tick bites are assumed to be the most frequent and most important primary sensitization source to α-Gal, and α-Gal syndrome is the first allergy classified as tick-borne disease. Left upper arc—administration of drugs derived from mammalian cells and tissue (like cetuximab, antivenom, gelatin in colloids or vaccines) can induce drug allergy. Left lower arc—as part of xeno-rejection, deterioration of biological heart valves is assumed. Right arc—consumption of mammalian muscle meat and innards, but also dairy products, gelatin in sweets or porcine pancreatic enzymes in digestion aids can induce food allergy