TABLE 2.
MICs and MBCs of TACN against South African clinical isolates
| Bacterial species and isolate | MBL produced (class B) | Other β-lactamase(s) produced | MEM with 8 mg/liter of TACN |
||
|---|---|---|---|---|---|
| MIC (mg/liter) | MBC (mg/liter) | MBC/MIC ratio | |||
| K. pneumoniae (n = 11) | |||||
| D(UNN40_S4) | NDM-1 | DHA-1, CTX-M-15, SHV-1, OXA-1 | 0.5 | 2 | 4 |
| C(UNN39_S3) | NDM-1 | SHV-1, CTX-M-15, OXA-1, DHA-1 | 0.5 | 2 | 4 |
| I(UNN45_S9) | NDM-1 | OXA-1, CTX-M-15, SHV-99, TEM-1B | 4 | 8 | 2 |
| J(UNN46_S10) | NDM-1 | OXA-1, CTX-M-15, SHV-1 and -28, DHA-7 | 0.5 | 2 | 4 |
| 53_S27 | NDM-1 | OXA-1, DHA-1, CTX-M-15, SHV-1 and -28 | 4 | 16 | 4 |
| 12_S5 | NDM-1 | CTX-M-15, SHV-1 and -28, DHA-1, OXA-1 | 2 | 8 | 4 |
| 13_S6 | NDM-1 | CTX-M-15, SHV-1 and -28, DHA-7 | 4 | 16 | 4 |
| 20_S11 | NDM-1 | CTX-M-15, TEM-1A, OXA-9, SHV-1 and -28, OXA-1 and -9 | 0.125 | 1 | 4 |
| 29_S13 | NDM-1 | CTX-M-15, SHV-1 and -28, OXA-1 and -9, TEM-1A | 0.125 | 1 | 4 |
| 32_S15 | NDM-1 | DHA-1, CTX-M-15, SHV-1 and -28, OXA-1 | 0.125 | 1 | 4 |
| 21_S12 | NDM-1 | TEM-1A, SHV-1 and -28, CTX-M-15, OXA1 and -9 | 0.5 | 1 | 2 |
| S. marcescens (n = 10) | |||||
| B(UNN38_S2) | NDM-1 | OXA-10, OXA-1, CTX-M-15, SCO-1, TEM-133, TEM-198 | 0.125 | 1 | 4 |
| E(UNN41_S5) | NDM-1 | CTX-M-15, SCO-1, TEM-198, OXA-10, OXA - 1 | 1 | 2 | 2 |
| G(UNN43_S7) | NDM-1 | OXA-10, TEM-1B | 1 | 4 | 4 |
| K(UNN47_S11) | NDM-1 | TEM-1B, OXA-1, OXA-10, SCO-1 | 2 | 16 | 8 |
| L(UNN48_S12) | NDM-1 | CTX-M-15, OXA-10, OXA -1, SCO-1, TEM-1 | 2 | 4 | 2 |
| 7_S3 | NDM-1 | TEM- 1B, OXA-10 | 2 | 8 | 4 |
| 56_S29 | NDM-1 | None | 0.5 | 2 | 4 |
| 59_S30 | NDM-1 | TEM-1B, CTX-M-3 | 1 | 2 | 2 |
| 67_S33 | NDM-1 | OXA-10, CTX-M -15, OXA-1, TEM-1, SCO-1 | 4 | 16 | 4 |
| 71_S36 | NDM-1 | CTX-M-11, TEM -1B, OXA -10, OXA-1, SCO-1 | 2 | 2 | 1 |
| E. cloacae (n = 9) | |||||
| A(UNN37_S1) | NDM-1 | CTX-M-3, ACT-3 | 0.5 | 1 | 2 |
| F(UNN42_S6) | NDM-1 | CTX-M-15, TEM -1B, OXA-1, ACT-7 | 0.5 | 2 | 4 |
| H(UNN44_S8) | NDM-1 | CTX-M-15, TEM -1B, OXA-1, ACT-14 | 1 | 1 | 1 |
| 16_S9 | NDM-1 | CTX-M-15, OXA-1, ACT-4 | 0.125 | 2 | 8 |
| 43_S20 | NDM-1 | TEM -1B, SHV-12, MIR-1 | 2 | 4 | 2 |
| 49_S24 | NDM-1 | CTX-M-15, TEM-1B, OXA-1, ACT-3, CMY-77 | 0.5 | 1 | 2 |
| 51 | NDM-1 | CTX-M-3, TEM-1B, CMY-77 | 0.25 | 1 | 4 |
| 55_S28 | NDM-1 | TEM -1B, ACT-4, SHV-12 | 4 | 2 | 2 |
| 63_S31 | NDM-1 | TEM-1B, ACT-1 | 0.5 | 2 | 4 |
| E. coli 10 (n = 1) | NDM-5 | CMY-42 | 2 | 4 | 2 |
| C. freundii 48 (n = 1) | NDM-1 | CTX-M-3, TEM-1B, CMY-77 | 0.25 | 2 | 4 |
| K. oxytoca 69 (n = 1) | NDM-1 | CTX-M-3, TEM-1B, OXY-14 | 0.25 | 2 | 4 |