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Illustration of the proposed BmrR regulation mechanism. (A) Under normal growth conditions, the active form of BmrR binds to the bmr box and represses transcription of the BmrRAB operon. (B) In the presence of ox bile, the DNA binding activity of BmrR is disrupted by ox bile. This modification results in the transcription of BmrAB ABC transporters to pump out ox bile.
