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. 2018 Dec;10(12):6585–6597. doi: 10.21037/jtd.2018.11.12

Figure 6.

Figure 6

The regulation and underlying molecular mechanism of periostin and TSLP expression in vitro. Human nasal epithelial cells (HNECs) from NPs tissues, were cultured in ALI. (A,B) The mRNA level of periostin (A), and the ELISA analysis of periostin (B), which added of IL-4, IL-13, TGF-β1 alone or with Leflunomide and PD98059 in the culture medium. (C,D) The mRNA level of TSLP (C), and the ELISA analysis of TSLP (D), which added of recombinant periostin alone or with S-PN1 or BAY 11-7082 in the culture medium. The periostin concentrations in NPs tissues was significantly associated with IL-4 (E), IL-13 (F), and TGF-β1 (G) concentrations. **, P<0.01, ***, P<0.001; as determined by Spearman analysis or Student’s t-test and Spearman analysis Figures are representative of three different experiments. TSLP, thymic stromal lymphopoietin; NP, nasal polyp; ALI, air-liquid interface.