Figure 4.

The addition of clinical features did not improve the AUC of the M_Radiomics (P=0.623), the M_MCNNs (P=0.114) and the M_{Radiomics+MCNNs} (P=0.058). The M_MCNNs outperformed the M_Radiomics (P=0.0225). The M_{MCNNs+Radiomics} did better than the M_Radiomics (P=0.009), but not the M_MCNNs (P=0.742). The M_MCNNs did not demonstrate inferiority compared with the M_{Radiomics+MCNNs} (P=0.742) and the M_{Radiomics+MCNNs+Clinical} (P=0.056) in terms of AUC. MCCNs, multi-level residual CNNs; CNN, convolutional neural network; AUC, area under the receiver operating characteristic curve; EGFR, epithelial growth factor receptor.