Table 1. Influenza A(H3N2) viruses detected in outbreaks, Yokohama, Japan, December 2018 (n = 4).
| GISAID isolate ID |
Isolate name | Onset of symptoms | Antiviral treatment |
Specimen collection | PA substitutiona |
|---|---|---|---|---|---|
| EPI_ISL_332908 | A/YOKOHAMA/133/2018 | 2 Dec 2018 | 3 Dec 2018 Baloxavir |
6 Dec 2018 | I38T (277Y) |
| EPI_ISL_332910 | A/YOKOHAMA/135/2018 | 4 Dec 2018 | 4 Dec 2018 Baloxavir |
7 Dec 2018 | I38T (Y277F) |
| EPI_ISL_332911 | A/YOKOHAMA/136/2018 | 4 Dec 2018 | 5–9 Dec 2018 Oseltamivir |
7 Dec 2018 | 38I (277Y) |
| EPI_ISL_332909 | A/YOKOHAMA/134/2018 | 6 Dec2018 | None | 7 Dec 2018 | 38I (Y277F) |
GISAID: Global Initiative on Sharing All Influenza Data; PA: polymerase acidic subunit.
aThe amino acid residue at position 277 is not involved in PA–inhibitor interactions.