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. 2018 Nov 8;47(2):634–647. doi: 10.1093/nar/gky1088

Figure 7.

Figure 7.

TbMCM-BP is required for silencing of subsets of VSG genes. (A) Schematic diagrams of VSG types; BES VSG (Bloodstream-form Expression Site VSG), MES VSG (metacyclic VSG), and MC VSG, (minichromosomal VSG). Reads from the RNA-seq experiment were aligned to the VSGnome database [16] and raw reads mapping to each VSG was analyzed with the DEseq. Log2(normalized count) values were obtained and graphed in scatter plots. (B) Scatter plots showing comparison between day 0 and day 1 for BES, MES or MC VSGs. Dotted diagonal lines indicate changes that are 4-fold up or down. (C) Scatter plots showing comparison between day 0 and day 2 for BES, MES or MC VSGs. Dotted diagonal lines indicate changes that are 4-fold up or down. (D, E) The rest of VSGs (‘Unknown’) excluding BES, MC, and MES were graphed in scatter plots. Plot D compares day 0 and day 1 and plot E compares day 0 and day 2. Red dots indicate VSG genes whose expression level changed significantly (Padj < 0.01). Dotted diagonal lines indicate changes that are 4-fold up or down.