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TbMCM-BP absence leads to DNA damage. (A) TbRPA1 forms nuclear foci in the absence of TbMCM-BP. TbMCM-BP cKO cells treated with tetracycline for 0 and 2 days were analyzed by immunofluorescence. Bulk DNA was stained with DAPI (blue) and TbRPA1 with rat anti-HA followed by secondary antibodies conjugated with A488 (green). (B) Level of RPA1-HA protein does not change upon TbMCM-BP removal. Western blot shows expression of TbMCM-BP-myc and TbRPA1-HA.
