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. 2018 Nov 12;47(2):648–665. doi: 10.1093/nar/gky1103

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — Evolutionary conservation of TAD borders. (A and B) The overlap of chicken and human (A) or chicken and mouse (B) Dixon TAD boundaries in syntenic regions. (C and D) The similarity of orthologs near Dixon TAD borders. All TAD borders were classified into six categories depending on the gene synteny level near the border. For example, if six genes are located near a given chicken TAD border, and five orthologs of these genes are jointly located near any TAD border in human genome, the intersection between sets will be 0.83 (83%) and the chicken TAD border will be classified as highly conserved (category >80% similarity). Gray bars indicate values obtained at random, with error bars showing three standard deviations.