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. Author manuscript; available in PMC: 2019 Jan 24.
Published in final edited form as: J Med Chem. 2018 May 7;61(10):4593–4607. doi: 10.1021/acs.jmedchem.8b00389

Figure 2.

Figure 2.

(A) Design justification for furoxan library. (B) Review of furoxan designation nomenclature. Furoxans tautomerize when heated sufficiently (at least 100 °C for a sustained period of time depending upon substitution pattern) but do not interconvert at physiologically relevant temperatures.