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. 2018 Nov 1;8(2):112–123. doi: 10.1002/sctm.18-0036

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© 2018 The Authors stem cells translational medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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mRNA‐induced midbrain dopaminergic (miDA) neurons express midbrain DA neuron markers. (A, B): FOXA2+/TUJ1+ and LMX1A+/TUJ1+ cells were immunostained and quantified in neuronal precursor cells (NPCs) from iPSC1 cells (day 5 of differentiation, scale bar: 100 μm). (C): TH+/TUJ1+ and GIRK2+/TUJ1+ cells were immunostained and quantified in miDA neurons from iPSC1 and iPSC2 cells (day 20 of differentiation, scale bar: 20 μm). (D, E): miDA neurons after in‐vitro maturation for 45 days were immunostained for midbrain DA neuron markers (NURR1, TH, and dopamine transporter [DAT]) and mature neuron marker synapsin (scale bar: 20 μm). Cell nuclei were counterstained with DAPI. Data represents mean ± SEM (n = 6).