Table 2.

Top 20 differential methylated CpG sites associated with dietary fiber intakes and sensitivity analysis

Rank	CpGs	CHR	Gene	Group	Model adjusted for covariates*			Model adjusted for covariates and folic acid*
					β**	p-value	FDR	β**	p-value	FDR
1	cg15200711	5p15.33	LPCAT1	Body	−0.039	4.53e–10	<0.001	−0.045	1.80E–09	0.001
2	cg19462022	13q34	RASA3	Body	−0.047	1.14e–09	<0.001	−0.049	8.20E–08	0.019
3	cg07035602	5p15.33	LPCAT1	Body	−0.016	4.63e–09	0.001	−0.017	1.90E–07	0.023
4	cg15302376	2p23.3	DNMT3A	5’UTR	−0.019	1.65e–07	0.019	−0.016	1.00E–04	0.505
5	cg26391080	10q23.1	SH2D4B	TSS1500	−0.021	9.31e–07	0.088	−0.020	5.40E–05	0.428
6	cg03589898				−0.020	1.36e–06	0.101	−0.019	6.60E–05	0.428
7	cg08740107				0.024	1.68e–06	0.101	0.032	1.90E–07	0.023
8	cg03394700	11p11.2	TP53I11	5’UTR	−0.027	1.71e–06	0.101	−0.031	3.80E–06	0.296
9	cg03462714	10p15.3	ADARB2	Body	−0.021	2.53e–06	0.113	−0.021	7.70E–05	0.452
10	cg01000812	20p13	LOC100288797	TSS200	−0.016	2.61e–06	0.113	−0.016	9.50E–05	0.494
11	cg06271327	17p13.1	VAMP2	3’UTR	−0.009	2.94e–06	0.113	−0.007	1.06E–03	0.707
12	cg09422701				−0.019	3.22e–06	0.113	−0.020	3.00E–05	0.428
13	cg25826698				−0.051	3.27e–06	0.113	−0.053	4.60E–05	0.428
14	cg25258002				−0.011	3.45e–06	0.113	−0.012	5.10E–05	0.428
15	cg21739719	15q24.2	C15orf27	Body	0.012	3.76e–06	0.113	0.014	2.50E–05	0.428
16	cg12405742	3p24.2	THRB	5’UTR	0.012	3.83e–06	0.113	0.011	3.12E–04	0.613
17	cg11813512				0.024	4.14e–06	0.115	0.022	5.31E–04	0.677
18	cg26159735				−0.009	6.21e–06	0.162	−0.009	2.16E–04	0.613
19	cg19641404	2q37.1	DIS3L2	TSS200	−0.014	6.74e–06	0.162	−0.015	8.10E–05	0.452
20	cg20257411	22q11.1	CECR5	Body;TSS200	0.003	6.86e–06	0.162	0.003	4.50E–05	0.428

^*Covariates include age, sex, BMI, energy intake

^**DNA methylation changes with 1 unit increase in square root transformed fiber intake.