Table 2.

Perinatal factors and methylation of CpG sites (categorical and ordinal variables)

Mother atopic	Mean [95% CI] Non-atopic	mean [95% CI] atopic			P-value
IL-2 Site 1	55.6 [54.1–57.2]	52.7 [51.6–53.8]			0.010
IL-2 Site 7	91.6 [91.1–92.0]	91.6 [91.3–92.0]			0.880
LINE-1	78.8 [78.5–79.2]	79.7 [79.5–80.0]			0.000
Maternal Asthma	no	yes
IL-2 Site 1	53.1 [51.8–54.4]	52.0 [50.0–54.0]			0.39
IL-2 Site 7	91.7 [91.3–92.2]	91.5 [90.9–92.1]			0.56
LINE-1	79.8 [79.5–80.2]	79.5 [79.1–79.9]			0.20
Cat owner	no	yes
IL-2 Site 1	53.9 [53.0–54.9]	51.0 [48.3–53.7]			0.02
IL-2 Site 7	91.6 [91.3–91.9]	91.7 [91.0–92.3]			0.94
LINE-1	79.5 [79.3–79.8]	79.3 [78.7–79.9]			0.44
Dog owner	no	yes
IL-2 Site 1	53.4 [52.4–54.4]	53.9 [51.9–56.0]			0.71
IL-2 Site 7	91.9 [91.2–92.6]	91.9 [91.2–92.6]			0.50
LINE-1	79.4 [79.2–79.7]	79.9 [79.3–80.5]			0.20
Paternal income (£/annum)	≤ 10000	10 K–20 K	20 K–30 K	≥ 30 K
IL-2 Site 1	53.4 [51.4–55.4]	52.6 [51.5–54.1]	55.0 [53.3–56.7]	54.8 [52.9–56.7]	0.14
IL-2 Site 7	91.7 [9.9–91.6]	91.5 [91.1–92.0]	91.8 [91.2–92.40]	92.4 [91.7–93.0]	0.01
LINE-1	79.9 [79.4–80.5]	79.5 [79.2–79.8]	79.6 [79.1–80.1]	79.2 [78.7–79.7]	0.29