Table 2.

Characteristics of RCA-CRRT

Study	Type of CRRT	Device of CRRT	Citrate infusion	Calcium infusion	CRRT doses (ml/h)	Blood flow (ml/min)	Postfilter ionCa target (mmol/l)	Serum ionCa target (mmol/l)	Mean filter lifetime (h)
Schultheiss et al. [9]	CVVHD	HF440/Multifiltrate	4ac	1.7be	2000	100	0.25–0.35	1.12–1.20	NR
Lahmer et al. [10]	SLED	Genius system	Local formula	10bd	9000	150	0.35–0.45	1.00–1.10	NR
Slowinski et al. [11]	CVVHD	Multifiltrate	4ac	1.7be	NR	NR	0.25–0.35	1.12–1.20	71.1
Sponholz et al. [18]	CVVHD	Multifiltrate	4ac	1.7be	2000	120	0.25–0.35	NR	29 ± 42.2
Durao et al. [19]	CVVHDF	Prisma M100/AN69 filter	140ad	70bd	2000	100	0.25–0.30	1.12–1.20	72 ± 22.2
De Vico et al. [20]	CVVHDF	Prismaflex System	Local formula	6.38bd	NR	182	0.20–0.40	NR	49.76 ± 22.10
Saner et al. [21]	CVVHD	Fresenius ADM08/F60S dialyzer	Local formula	10% calcium gluconate	1000	75–100	< 0.30	> 0.95	22.7 ± 14.6
Balogun et al. [22]	NR	Prisma system/ST150 filter	180d	10bd	2000	180	NR	NR	62.4
Klingele et al. [23]	CVVHD	Multifiltrate-CiCa	4ac	1.7be	2000	100	0.25–0.35	NR	62.2 ± 11.2
Yu et al. [24]	NR	Gambro Prismaflex/AN69-M100 filter	NR	5%b	35 ml/h kg	3 ml/min·kg	0.25–0.45	1.0–1.2	44.2

Abbreviations: CRRT continuous renal replacement therapy, CVVHD continuous veno-venous hemodialysis, CVVHDF continuous veno-venous hemodiafiltration, ionCa ionized calcium, NR not reported, RCA regional citrate anticoagulation, SLED sustained low-efficiency dialysis

^a4% trisodium citrate

^bCalcium chloride

^cmmol/l blood

^dml/h

^emmol/l