Fig. 7.

a Venny diagram represented common and unique protein markers from the RF classifier to distinct type 2 diabetes, CAD, and T2DM_CAD as compared with control. b Protein markers that responsible for development and progression of diabetes and associated coronary artery disease complication. Different pathological protein markers i.e., adipokines, cytokines, metabolic hormones and apolipoproteins (markers which were classified in RF classifier Table 3) may act as mediators in the initiation of insulin resistance, systemic inflammation, endothelial dysfunction and increase lipolysis and free fatty acids. Up arrow resembles upregulated proteins and down arrow resembles downregulated markers