Table 2.

Effect of compounds 16, 17a, 17b, 19a-19j on TRPC6 channels

Compd	R1	R2	R3	TRPC6 IC50(μ(Ha))
16	H	H	MeCH2O	NA
17a	Me	Me	MeCH2O	NA
17b	Et	Et	MeCH2O	NA
19a	H	H		> 30
19b	Me	Me		> 100
19c	Et	Et		> 100
19d	H	H		> 30
19e	H	H		> 30
19f	H	H		> 100
I9g	H	H		NA
19h	H	H		> 50
19i	H	H		> 50
19j	H	H		> 50

^aEffects on TRPC6 or IC₅₀ against activation by 10 μM 4o, estimated based on one experiment with triplicates, NA: No activity.