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. 2019 Jan 21;14:753–769. doi: 10.2147/IJN.S187929

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© 2019 Chen et al. This work is published and licensed by Dove Medical Press Limited

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Comparison of essential properties for developed NPs.

Notes: (A, B) Absorption and fluorescence spectra of free ICG, OI_PNPs, TOI_LNPs, and TOI_HNPs. (C, D) Normalized absorption and fluorescence intensity of free ICG, OI_PNPs, TOI_LNPs, and TOI_HNPs every 3 days. (E) The size stability of OI_PNPs, TOI_LNPs, and TOI_HNPs at different time intervals. (F) The change of the dissolved oxygen concentration levels for prepared solutions before and after laser plus US treatment. (G) Release profile of ICG from OI_PNPs, TOI_LNPs, and TOI_HNPs in PBS and in BSA at 37°C and 100 rpm.

Abbreviations: ICG, indocyanine green; LPHNPs, lipid–polymer hybrid nanoparticles; NPs, nanoparticles; OI_PNPs, PLGA NPs-encapsulated ICG and PFP-carrying oxygen; PFP, perfluoropentane; PLGA, poly (lactic-co-glycolic acid); TOI_HNPs, folate-targeted LPHNPs-loaded ICG/PFP-carrying oxygen; TOI_LNPs, folic-targeted lipid NPs-encapsulated ICG and PFP-carrying oxygen; US, ultrasound; FL, fluorescence.

Comparison of essential properties for developed NPs.

Notes: (A, B) Absorption and fluorescence spectra of free ICG, OI_PNPs, TOI_LNPs, and TOI_HNPs. (C, D) Normalized absorption and fluorescence intensity of free ICG, OI_PNPs, TOI_LNPs, and TOI_HNPs every 3 days. (E) The size stability of OI_PNPs, TOI_LNPs, and TOI_HNPs at different time intervals. (F) The change of the dissolved oxygen concentration levels for prepared solutions before and after laser plus US treatment. (G) Release profile of ICG from OI_PNPs, TOI_LNPs, and TOI_HNPs in PBS and in BSA at 37°C and 100 rpm.

Abbreviations: ICG, indocyanine green; LPHNPs, lipid–polymer hybrid nanoparticles; NPs, nanoparticles; OI_PNPs, PLGA NPs-encapsulated ICG and PFP-carrying oxygen; PFP, perfluoropentane; PLGA, poly (lactic-co-glycolic acid); TOI_HNPs, folate-targeted LPHNPs-loaded ICG/PFP-carrying oxygen; TOI_LNPs, folic-targeted lipid NPs-encapsulated ICG and PFP-carrying oxygen; US, ultrasound; FL, fluorescence.