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. 2019 Jan 21;14:753–769. doi: 10.2147/IJN.S187929

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© 2019 Chen et al. This work is published and licensed by Dove Medical Press Limited

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Dual-mode imaging in vitro agar-gel model.

Notes: (A) B mode and CEUS imaging of particles before and after laser irradiation for degassed water, free ICG, TO_HNPs, and TOI_HNPs. (B, C) The semi-quantitative of EI in B mode and CEUS before and after laser irradiation. (D) US mode and PA mode imaging for the same groups before and after laser irradiation. (E, F) The semi-quantitative of EI in US mode and PA average value in PA mode before and after laser irradiation. TOI_HNPs of post-irradiation compared with the pre-irradiation, *P<0.05; after laser irradiation, TOI_HNPs compared with the other groups at the same conditions, ^#P<0.05.

Abbreviations: CEUS, contrast-enhanced ultrasound; EI, echo intensity; ICG, indocyanine green; LPHNPs, lipid–polymer hybrid nanoparticles; PFP, perfluoropentane; TOI_HNPs, folate-targeted LPHNPs-loaded ICG/PFP-carrying oxygen; US, ultrasound; TO_HNPs, folate-targeted LPHNPs-loaded PFP-carrying oxygen.