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. 2019 Jan 21;14:753–769. doi: 10.2147/IJN.S187929

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© 2019 Chen et al. This work is published and licensed by Dove Medical Press Limited

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Therapeutic effect in SKOV3 cells after different treatments.

Notes: (A) Cytotoxicity of TOI_HNPs using the MTT assay at a concentration of ICG for 0–128 µg/mL. (B) Cell viability of SKOV3 cells under different treatments was determined by the MTT assay (8 µg/mL of ICG). (C, D) Apoptosis detected by flow cytometry 24 hours after different treatments. Compared with control, *P<0.05; compared with other groups, ^#P<0.05.

Abbreviations: ICG, indocyanine green; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide; PFP, perfluoropentane; PSDT, photo–sonodynamic therapy; LPHNPs, lipid–polymer hybrid nanoparticles; TOI_HNPs, folate-targeted LPHNPs-loaded ICG/PFP-carrying oxygen; FITC, fluorescein isothiocyanate.