Table 1.
Physicochemical property of the fabricated NPs
| Groups | Size (nm) | PDI | Zeta potential (mV) | EE (%) | LE (%) |
|---|---|---|---|---|---|
|
| |||||
| TOI_HNPs | 166.83±5.54 | 0.183±0.092 | −30.57±1.36 | 75.29±2.92 | 1.02±0.04 |
| OI_PNPs | 214.50±10.87 | 0.136±0.051 | −24.04±1.17 | 62.48±3.39 | 1.84±0.10 |
| TOI_LNPs | 340.47±16.06 | 0.149±0.061 | −17.50±1.65 | 82.50±2.84 | 2.20±0.08 |
| TO_HNPs | 170.07±1.63 | 0.083±0.063 | −28.33±1.50 | – | – |
| TI_HNPs | 171.53±4.68 | 0.056±0.008 | −27.27±1.64 | – | – |
Note: Values are represented as mean ± SD (n=3).
Abbreviations: EE, encapsulation efficiency; ICG, indocyanine green; LE, loading efficiency; NPs, nanoparticles; PDI, polydispersity; PFP, perfluoropentane; LPHNPs, lipid– polymer hybrid nanoparticles; TOI_HNPs, folate-targeted LPHNPs-loaded ICG/PFP-carrying oxygen; OI_PNPs, PLGA NPs-encapsulated ICG and PFP-carrying oxygen; PLGA, poly (lactic-co-glycolic acid); TOI_LNPs, folic-targeted lipid NPs-encapsulated ICG and PFP-carrying oxygen; TO_HNPs, folate-targeted LPHNPs-loaded PFP-carrying oxygen; TI_HNPs, folate-targeted LPHNPs-loaded ICG.