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. 2019 Jan 17;9:1563. doi: 10.3389/fphar.2018.01563

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Copyright © 2019 Gugliandolo, Fusco, D’Amico, Peditto, Oteri, Di Paola, Cuzzocrea and Navarra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological aspect of LPS-induced periodontitis in rats. Fourteen days after the start of experiments, gingivomucosal tissues from LPS-injected rats showed oedema, tissue injury and inflammatory cells infiltration (B,G) compared to the rats of sham-group (A,G). BJe treatment significantly reduced the inflammatory picture LPS-induced (C,G). Moreover, Masson’s trichrome stain, presented increase in the concentration of collagen fibers in gingivomucosal tissues in vehicle group (E,H) when compared with sham group (D,H). Treatment with BJe significantly attenuated collagen formation (F,H). Values are expressed as mean ± SEM (N = 10 rats in each group). ^∗P < 0.05 vs sham group. °P < 0.05 vs LPS group.