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Treatment with BIO-11006 attenuates pulmonary but not nasal airflow obstruction during MCh challenge. MCh-induced increase in pulmonary and nasal airway resistance (mean ± SD, shaded and open bars, respectively) is shown for mice pretreated with 10 mM RNS (left, n = 10); 5 mM BIO-11006 (BIO6, middle, n = 8); and 10 mM BIO-11006 (BIO6, right, n = 8). A: the response to 60 mM MCh; B: the response to 120 mM MCh.
