Table 1.

Univariate and multivariable overall survival analyses with ZEB1 alone and IDH/ZEB1 in addition to clinical variables in patients with grade II/III gliomas.

Variable	Univariate			Multivariable
				With ZEB1a		With IDH/ZEB1b		Clinical Variablesc
	N	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value
Age at diagnosis	334	1.07 (1.05–1.10)	<0.001	1.06 (1.04–1.09)	<0.001	1.06 (1.04–1.08)	<0.001	1.07 (1.05–1.09)	<0.001
Histologic type			0.073*
Astrocytoma	112	1.88 (1.08–3.30)	0.027	†		†		Not included
Ambiguous histology**	87	1.16 (0.57–2.35)	0.677
Oligodendrogliomas	135	1 (Reference)
GRADE
II	153	0.32 (0.18–0.56)	<0.001	0.55 (0.30–1.01)	0.056	0.56 (0.30–1.03)	0.060	0.38 (0.21–0.67)	<0.001
III	181	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
1p/19q CO-DELETION STATUS
True	76	0.51 (0.26–0.99)	0.048	†		†		Not included
False	138	1 (Reference)
ZEB1
CN deletion	63	7.20 (4.24–12.24)	<0.001	4.25 (2.35–7.66)	<0.001	Not included		Not included
Wildtype	271	1 (Reference)		1 (Reference)
IDH/ZEB1			<0.001*				<.001*
IDHmut-ZEB1wt	257	0.07 (0.04–0.13)	<0.001	Not included		0.13 (0.06–0.27)	<0.001	Not included
IDHwt-ZEB1wt	14	0.16 (0.05–0.48)	0.001			0.31 (0.10–0.97)	0.044
IDHmut-ZEB1del	8	0.18 (0.06–0.57)	0.004			0.26 (0.08–0.85)	0.026
IDHwt-ZEB1del	55	1 (Reference)				1 (Reference)
Optimism-corrected c-statistic (95% CI)				0.832 (0.745, 0.919)		0.841 (0.754, 0.928)		0.813 (0.726, 0.900)

^*Overall p-value for variables with more than two categories.

^**Formerly Oligoastrocytoma.

^†Dropped out of the final model.

334 observations were used in multivariable models.

^aMultivariable model including ZEB1 as well as clinical variables.

^bMultivariable model including IDH/ZEB1 as well as clinical variables.

^cBase model without a predictor variable of either ZEB1 alone or IDH/ZEB1.