Table 5.

Comparison of hiPSC-based disease modeling approaches

	Innate	Engineered	Induced
+	Disease modeled against patients' genetic background	↓Need for patient recruitment	Enables modeling of noncongenital conditions
		Isogenic disease and control lines
−	Patient recruitment difficult	Time consuming	Induced conditions may not accurately recapitulate disease
	Nonisogenic disease and control lines	Costly
		Potential risk for genomic instability

The advantages (+) and disadvantages (−) of innate, induced, and engineered hiPSC-based disease models. ↓, Reduced.