FIGURE 6.

Transcription factors and signaling molecules participating in regulation of MSC differentiation. Various molecules and factors induce MSC differentiation into several cell lines. BMP-2, bone morphogenetic protein-2; EGF, epidermal growth factor; FGF-2, fibroblast growth factor-2; LRP5/6, low-density lipoprotein receptor-related protein-5/6; MEF2, myocyte enhancer factor-2; MRF, myogenic regulatory factors; Osx, Osterix; PDGF, platelet-derived growth factor; RUNX2, runt-related transcription factor-2; TGF-β, transforming growth factor-β; VEGF, vascular endothelial growth factor. [Adapted from Karantalis et al. (173).]