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. Author manuscript; available in PMC: 2019 Jan 24.
Published in final edited form as: Neuroscience. 2018 Apr 18;381:11–21. doi: 10.1016/j.neuroscience.2018.04.005

Fig. 2.

Fig. 2.

Effects of orexin 1 receptor antagonist on anxiety-related open-field behaviors and darting behavior in adolescent and adult rats. Animals were injected with vehicle or SB334867 (1, 10, or 30 mg/kg i.p.) 30 min prior to being placed in an open-field arena for 30 min. Adolescent data are shown in the left column, adult data in the right column. Number of Center Zone Entries (A), Time Spent in Center Zone (B), Latency to Enter Center Zone (C), and the Number of Darts (D) in vehicle- and SB334867-treated groups in adolescent and adult rats were analyzed and represented as average ± SEM. Significant main effect of sex is indicated by * between sex groups on the x-axis. Significant differences are represented as: *p < 0.05.