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Concentrations of TFV-DP (green) and FTC-TP (blue) in PBMCs from three rhesus macaques at the indicated time points analyzed by LC-MS/MS. Data points represent mean ± SEM. Horizontal dotted line represents preventative target concentration for effective PrEP. Vertical dotted line represents day of transcutaneous refilling of NDI implants (day 70). Animals were euthanized on day 83.
