Figure 6. The IL-17A/IL-33/Areg cascade in influenza-infected children is associated with robust disease outcome.
A- C. Correlation between concentrations of human IL-17A and IL-33 (A), IFN-γ and IL-33 (B) and IL-33 and Areg protein levels (C) in the nasal aspirates of influenza-infected children (< 8 years old, n=51).D. Concentration of IL-17A at Day 0 after enrollment in the nasal aspirates of children with mild (black, n=11) and severe (red, n=12) influenza disease outcomes.E. Concentration of IFN-γ at Day 0 after enrollment in the nasal aspirates of children with mild (black, n=11) and severe (red, n=12) disease outcomes.Data are presented as mean ± SEM, and in each case cytokine values (pg/ml) were log10 transformed for visualization only. *p<0.05.