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Free energy ∆G as a function of the force for the coil state, the terminator, and the aptamer structure. The free energy profiles give the equilibrium unfolding forces 11 pN and 8 pN for the terminator hairpin and the adenine-bound aptamer, respectively. In the free energy calculations, we use GBIND = 5.3 kcal/mol for the ligand-induced additional stability of the aptamer.
