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. 2019 Feb 1;10(1):71–81. doi: 10.14336/AD.2018.0117

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Copyright: © 2019 Cardellini et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 1. — Characterization of nodular calcification. A-D) Histological and ultrastructural characterization of calcifications in carotid plaques. (A) Stable fibrocalcific plaque with a linear calcification (Movat staining,2x); (B) Calcific carotid nodule protruding into the lumen consisting of calcified plates associated to a small amount of fibrous tissue without extracellular lipids, necrotic core and inflammatory cells. The fibrous cap over the nodule was extremely thin (Movat staining, 5x); (C, D) Images display a calcific nodule associated to fibrin deposition with a small superficial ulceration (C): Movat staining, 2x, D (particular of C): 6x). (E-H) Scanning electron microscopy and EDX microanalysis of carotid plaque: (E) The image shows an eruptive calcific nodule with disruption of fibrotic cap (scanning electron microscopy, 100x); (F) EDX spectrum shows that this calcific nodule is made from hydroxyapatite; (G) Linear calcification in a stable fibrocalcific carotid plaque (scanning electron microscopy, 90x); (H) EDX spectrum demonstrates that this linear calcification is made from calcium oxalate.